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David LeBrun

 
  Molecular mechanisms of leukemogenesis

 
  Contact Information:  
  Associate Professor of Pathology Residency in Anatomical Pathology (University of Toronto); Postdoctoral Fellowship (Stanford University).

Tel: (613) 548-1302
Fax: (613) 533-2907
email: lebrun@cliff.path.queensu.ca


 
  Molecular mechanisms of leukemogenesis. Pre-B cell acute lymphoblastic leukemia is predominantly a disease of childhood. Many cases are associated with a chromosomal translocation, t(1;19), that leads to expression of an abnormal, chimeric transcription factor, E2A-PBX1.

Studies being undertaken in my lab are directed at elucidating oncogenic effects mediated by this protein and mechanisms by which these are produced. Currently of particular interest are protein-protein interactions and post-translationsl modifications involving the E2A portion of the protein.



 
  Publications:  
  N/A